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Cover Illustration: Crystal structure of an E. coli Thi-box riboswitch bound to benfotiamine (Protein Data Bank code: 2hoo; Nucleic Acid Database code: ur0103; Edwards, T.E. and Ferré-D'Amaré, A.R. 2006. Crystal structures of the Thi-box riboswitch bound to thiamine pyrophosphate analogs reveal adaptive RNA-small molecule recognition. Structure 14: 1459–1468). Image details: RNA: ribbon-plate representation, A—red, U—magenta, G—green, C—blue; Ca ions, benfotiamine: space-filling representation. The image was generated with the Accelrys Discovery Studio Visualizer. Cover image provided by the Jena Library of Biological Macromolecules—JenaLib (www.fli-leibniz.de/IMAGE.html).