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Cover Illustration: Crystallographic asymmetric unit of the signal recognition particle (SRP) protein SRP54 complexed with helix 8 of SRP RNA from the archaeon Sulfolobus solfataricus (Protein Data Bank code: 1qzw; protein: ribbon representation, chain-specific coloring; RNA: space-filling representation, chain-specific coloring). The image was generated with the Accelrys Discovery Studio Visualizer. Cover image provided by the Jena Library of Biological Macromolecules-JenaLib (www.fli-leibniz.de/IMAGE.html).