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Cover Illustration: Solution structure of HIV-1 TAR RNA in the absence of ligands. [Protein Data Bank code: 1anr; model 1; space-filling representation; the unbound trans-activation response element (TAR) bulge is displayed as sticks; color scheme: A, red; C, blue; G, green; U, magenta.] The image was generated with InsightII from Accelrys,Inc. Cover image provided by IMB Jena Image Library of Biological Macromolecules (www.imb-jena.de/IMAGE.html).