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This Article OPEN ACCESS ARTICLE Full Text Full Text (PDF) Supplemental Research Data All Versions of this Article: rna.988608v1 14/5/822    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Weinberg, Z. Articles by Breaker, R. R. PubMed PubMed Citation Articles by Weinberg, Z. Articles by Breaker, R. R. Social Bookmarking                   What's this?

The aptamer core of SAM-IV riboswitches mimics the ligand-binding site of SAM-I riboswitches

¹ Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520-8103, USA
² Howard Hughes Medical Institute, Yale University, New Haven, Connecticut 06520-8103, USA
³ Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520-8103, USA
⁴ Department of Computer Science and Engineering, University of Washington, Seattle, Washington 98195-2350, USA
⁵ Department of Genome Sciences, University of Washington, Seattle, Washington 98195-2350, USA

A novel family of riboswitches, called SAM-IV, is the fourth distinct set of mRNA elements to be reported that regulate gene expression via direct sensing of S-adenosylmethionine (SAM or AdoMet). SAM-IV riboswitches share conserved nucleotide positions with the previously described SAM-I riboswitches, despite rearranged structures and nucleotide positions with family-specific nucleotide identities. Sequence analysis and molecular recognition experiments suggest that SAM-I and SAM-IV riboswitches share similar ligand binding sites, but have different scaffolds. Our findings support the view that RNA has considerable structural versatility and reveal that riboswitches exploit this potential to expand the scope of RNA in genetic regulation.

Keywords: AdoMet; S-adenosylmethionine; riboswitches; scaffold; Streptomyces

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