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Published online before print January 22, 2008, 10.1261/rna.848208
RNA (2008), 14:404-409. Published by Cold Spring Harbor Laboratory Press. Copyright © 2008 RNA Society.
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MINI-REVIEW

Trading translation with RNA-binding proteins

Irina Abaza and Fátima Gebauer

Centre de Regulació Genòmica (CRG), Gene Regulation Programme, 08003 Barcelona, Spain

RNA-binding proteins regulate every aspect of RNA metabolism, including pre-mRNA splicing, mRNA trafficking, stability, and translation. This review summarizes the available information on molecular mechanisms of translational repression by RNA-binding proteins. By using a specific set of well-defined examples, we also describe how regulation can be reversed.

Keywords: translation; RNA-binding proteins; hnRNP K; SXL; Maskin; Cup; IRP; GAIT; CPEB; Smaug


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