Global analysis of mRNA splicing

  1. Michael J. Moore and
  2. Pamela A. Silver
  1. Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, USA

Abstract

Alternative mRNA splicing is a rich source of transcript diversity in eukaryotic cells with broad roles in development and disease. Systems-wide experimental methods have started to define how global splicing regulation shapes complex biological properties and pathways. Here, we review these approaches, describe recent insights they have yielded, and discuss avenues of future investigation.

Keywords

Footnotes

  • Reprint requests to: Pamela A. Silver, Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA; e-mail: pamela_silver{at}hms.harvard.edu; fax: (617) 432-5012.

  • Article published online ahead of print. Article and publication date are at http://www.rnajournal.org/cgi/doi/10.1261/rna.868008.

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  1. Published in Advance December 14, 2007, doi: 10.1261/rna.868008 RNA 2008. 14: 197-203 Copyright © 2008 RNA Society

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