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Published online before print June 11, 2007, 10.1261/rna.554607
RNA (2007), 13:1155-1171. Published by Cold Spring Harbor Laboratory Press. Copyright © 2007 RNA Society.
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REVIEW

The impact of alternative splicing in vivo: Mouse models show the way

Tarik Möröy and Florian Heyd

Institut de Recherches Cliniques de Montréal, IRCM, Département de Microbiologie et Immunologie, Université de Montréal, Montreal, QC, H2W 1R7, Canada

Alternative splicing is widely believed to have a major impact on almost all biological processes since it increases proteome complexity and thereby controls protein function. Recently, gene targeting in mice has been used to create in vivo models to study the regulation and consequences of alternative splicing. The evidence accumulated so far argues for a nonredundant, highly specific role of individual splicing factors in mammalian development, and furthermore, demonstrates the importance of distinct protein isoforms in vivo. In this review, we will compare phenotypes of mouse models for alternative splicing to crystallize common themes and to put them into perspective with the available in vitro data.

Keywords: alternative splicing; mouse models


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